Leucine, N-[(1,1-dimethylethoxy)carbonyl]- - Names and Identifiers
Leucine, N-[(1,1-dimethylethoxy)carbonyl]- - Physico-chemical Properties
Molecular Formula | C11H21NO4
|
Molar Mass | 231.29 |
Density | 1.061±0.06 g/cm3(Predicted) |
Boling Point | 356.0±25.0 °C(Predicted) |
pKa | 4.02±0.21(Predicted) |
Leucine, N-[(1,1-dimethylethoxy)carbonyl]- - Introduction
Leucine, N-[(1,1-dimethylethoxy)carbonyl]-is a chemical substance with the chemical name N-[(1,1-dimethylethoxy)carbonyl]-leucine. The following is an introduction to its nature, use, preparation and safety information:
Nature:
- Leucine, N-[(1,1-dimenthylethoxy) carbonyl]-is a white crystalline solid.
-It is relatively stable at room temperature and easily soluble in organic solvents such as methanol, chloroform and dimethylformamide.
-It is a non-natural amino acid derivative and is a protecting group of leucine.
Use:
- Leucine, N-[(1,1-dimenthylethoxy) carbonyl]-is often used as an important intermediate in organic synthesis.
-It can be used for peptide synthesis and solid phase synthesis.
-Because it has a protective function, it can prevent leucine from reacting during the synthesis process.
Preparation Method:
- Leucine, N-[(1,1-dimenthylethoxy) carbonyl]-is usually prepared by taking leucine and then reacting it with a reactive carboxylic acid anhydride (such as scopolamine anhydride) to form the Boc-leucine transition product.
-Then, by using a solution of N,N-dimethylformamide piperidine and a suitable base catalyst, this intermediate product is acylated to generate Leucine, N-[(1,1-dimethyllethoxy) carbonyl]-.
Safety Information:
- Leucine, N-[(1,1-dimenthylethoxy) carbonyl]-It is usually relatively safe under correct use and storage.
-However, it may cause irritation to the eyes, skin and respiratory tract. Please pay attention to personal protective measures during operation, such as wearing gloves, goggles and respiratory protection equipment.
-When using and handling, it is best to operate in a well-ventilated laboratory environment to avoid inhalation or contact.
Last Update:2024-04-09 21:32:43